Work package 1.
Effects of maternal diabetes and/or obesity on early embryo metabolism
WP1A: The rabbit embryo model
WP1B: Cellular models
Work package 2.
Human ART and mouse models: detecting the origin and propagation of periconception disease pathways
WP2A: Human ART model
WP2B: Mouse embryo and cellular model
Work package 3.
Periconceptional epigenetic programming mechanisms in knock-out mouse and stem cell models
Work package 4.
Analyses of epigenetically regulated genes of LLI compared with human perinatal profiles
Work package 5.
Data mining, bioinformatics pathway analyses and modelling of pathways and intervention methods
WP5A Data mining and bioinformatics
WP5B Modelling and development of epigenetic and metabolic intervention methods for healthy periconceptional development
Work package 6.
Management, training and dissemination